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孙文社

 

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孙文社

男,1988年出生,青岛大学博士后。主要从事多功能磁性纳米材料调控肿瘤免疫微环境的研究,包括肿瘤靶向,多模态成像、多种免疫细胞评价、肿瘤免疫检验点治疗等。参与国家重点研发计划项目;国家转化医学基金(上海)开放基金项目;上海市教委创新研究计划项目;国家自然科学基金项目等。

2008 – 2012年在山东交通学院获得航海技术学位;2012 – 2015年在华东师范大学从事分子生物学研究并取得硕士研究生学位;博士2015 – 2021在上海交通大学生物医学工程学院从事超顺磁性磁共振造影剂的临床前研究和多功能磁性纳米材料调控肿瘤免疫微环境的研究,包括肿瘤靶向,多模态成像、多种免疫细胞流式分析、肿瘤免疫检验点治疗等。探索用较低剂量有效的诱导肿瘤细胞程序性死亡,降低药物的心脏毒性等问题,从而达到减少并发症的同时提高治疗效率。减少目前临床放化疗面临的疗效和毒副作用的矛盾。

2021年7月进入青岛大学肿瘤研究院从事博士后研究工作。目前主要参与抗体药物的开发和药效评估,新型心肌保护剂的研制及应用,放射性粒子的临床诊断和生物学效应,肿瘤微环境调控,分子影像诊断等领域。

代表性科研成果:

[1] Sun W, Yang J, Hou M, et al. A Nano ‘Immune-guide’ Recruiting Lymphocytes and Modulating the Ratio of Macrophages from Different Origins to Enhance Cancer Immunotherapy [J]. Advanced Functional Materials。DOI: 10.1002/adfm.202009116. (第一作者)

[2] Xie S, Sun W, Zhang C, et al. Metabolic control by heat stress to determine the transformation of cell fate between ferroptosis and non-ferroptotic death for effective cancer therapy [J]. ACS Nano 2021, 15, 4, 7179–7194 (共同第一作者)

[3] Yang J, Hou M, Sun W, et al. Sequential PDT and PTT Using Dual-Modal Single-Walled Carbon Nanohorns Synergistically Promote Systemic Immune Responses against Tumor Metastasis and Relapse [J]. Adv. Sci. 2020, 2001088 (共同作者)



Sun wenshe, male, born in 1988, is a postdoctoral student of Qingdao University. Mainly engaged in the research on the regulation of tumor immune microenvironment by multifunctional magnetic nanomaterials, including tumor targeting, multimodal imaging, multiple immune cell evaluation, tumor immune checkpoint therapy, etc. Participate in national key R & D projects; National translational medicine foundation (Shanghai) open fund project; Innovation research program of Shanghai Education Commission; National Natural Science Foundation of China, etc.

From 2008 to 2012, obtained a degree in navigation technology from Shandong Jiaotong University; From 2012 to 2015, engaged in molecular biology research in East China Normal University and obtained a master's degree; From 2015 to 2021, engaged in preclinical research on superparamagnetic magnetic resonance contrast agents and Research on the regulation of tumor immune microenvironment by multifunctional magnetic nanomaterials, including tumor targeting, multimodal imaging, flow cytometry of multiple immune cells, tumor immune checkpoint therapy, etc. To explore the effective induction of programmed death of tumor cells with lower dose and reduce the cardiotoxicity of drugs, so as to reduce complications and improve treatment efficiency. Reduce the contradiction between efficacy and toxic and side effects faced by clinical radiotherapy and chemotherapy.

In July 2021, entered the Cancer Research Institute of Qingdao University to engage in post-doctoral research. At present, it is mainly involved in the development and efficacy evaluation of antibody drugs, the development and application of new myocardial protective agents, clinical diagnosis and biological effects of radioactive particles, tumor microenvironment regulation, molecular imaging diagnosis and other fields.

Representative scientific research achievements:

[1] Sun W, Yang J, Hou M, et al. A Nano ‘Immune-guide’ Recruiting Lymphocytes and Modulating the Ratio of Macrophages from Different Origins to Enhance Cancer Immunotherapy [J]. Advanced Functional Materials。DOI: 10.1002/adfm.202009116. (The first author)

[2] Xie S, Sun W, Zhang C, et al. Metabolic control by heat stress to determine the transformation of cell fate between ferroptosis and non-ferroptotic death for effective cancer therapy [J]. ACS Nano 2021, 15, 4, 7179–7194 (Co-first author)

[3] Yang J, Hou M, Sun W, et al. Sequential PDT and PTT Using Dual-Modal Single-Walled Carbon Nanohorns Synergistically Promote Systemic Immune Responses against Tumor Metastasis and Relapse [J]. Adv. Sci. 2020, 2001088 (co-author)